产品货号：
Z21000
中文名称：
MKK7/MAP2K7抗体
英文名称：
Anti-MKK7/MAP2K7 Antibody (C-Term)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MKK7/MAP2K7 Antibody (C-Term) |
| 指标别名 | JNK activating kinase 2;JNK kinase 2;JNKK 2;Jnkk2;MAP kinase kinase 7;MAP2K7;MAPK/ERK kinase 7;MAPKK 7;MAPKK7;MEK 7;MEK7;MKK7;PRKMK7 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | MAP2K7 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This MAP2K7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 363-396 amino acids of human MAP2K7. |
| 计算分子量 | 47kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.With MAP2K4/MKK4,is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1,MAPK9/JNK2 and MAPK10/JNK3.MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation,but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif.MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue.The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity,while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation.Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines.The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway,including the release cytochrome c,leading to apoptosis. |
| Uniprot ID | O14733 |
| 推荐稀释比 | Western blot 1:500～2000 |
相关搜索：MKK7/MAP2K7抗体，MKK7抗体，MAP2K7(C-Term)多抗，Anti-MKK7/MAP2K7 Antibody (C-Term)